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Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

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The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment. facilitating calcium-release-dependent cellular processes. ER calcium depletion robustly activates the unfolded protein response (UPR). However. https://danddcollectiblers.shop/product-category/journey-tote/
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